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Phenotypes Associated with This Genotype
Genotype
MGI:3689179
Allelic
Composition
Ryr2tm1Slh/Ryr2+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm1Slh mutation (0 available); any Ryr2 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ryr2tm1Slh/Ryr+ MRI heart images

cardiovascular system
• systolic function is modestly reduced as demonstrated by decreased peak of aortic velocity
• exhibit a lowered right ventricular end-diastolic volume and higher right ventricular end-diastolic pressure, indicating restrictive ventricular filling, however show no evidence of fibrofatty infiltration or arrhythmogenic right ventricular dysplasia
• develop ventricular tachycardia after caffeine and epinephrine injection or with programmed ventricular stimulation
• multiple premature ventricular beats are seen after isoproterenol treatment (a beta-adrenergic receptor agonist), however no sustained ventricular arrhythmias are seen
• isolated cardiomyocytes exhibit a higher incidence of spontaneous calcium oscillations in the absence and presence of isoproterenol

muscle
• systolic function is modestly reduced as demonstrated by decreased peak of aortic velocity
• exhibit a lowered right ventricular end-diastolic volume and higher right ventricular end-diastolic pressure, indicating restrictive ventricular filling, however show no evidence of fibrofatty infiltration or arrhythmogenic right ventricular dysplasia


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory