Mouse Genome Informatics
ht
    Pou4f3tm1Rsd/Pou4f3+
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hearing/vestibular/ear
N
• at 2, 18 and 24 months of age, heterozygotes exhibit a comparable hearing to wild-type mice, with similar patterns of cochlear degeneration (J:57149)
• both heterozygous and wild-type mice display a ~30 dB hearing loss beginning at 18 months of age, outer hair cell degeneration and loss of spiral ganglion neurons in the basal turn (J:57149)

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Deafness, Autosomal Dominant 15; DFNA15 602459 J:57149