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Phenotypes Associated with This Genotype
Genotype
MGI:3688923
Allelic
Composition
Pou4f3tm1Rsd/Pou4f3+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f3tm1Rsd mutation (0 available); any Pou4f3 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
N
• at 2, 18 and 24 months of age, heterozygotes exhibit a comparable hearing to wild-type mice, with similar patterns of cochlear degeneration
• both heterozygous and wild-type mice display a ~30 dB hearing loss beginning at 18 months of age, outer hair cell degeneration and loss of spiral ganglion neurons in the basal turn

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Deafness, Autosomal Dominant 15; DFNA15 602459 J:57149


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory