Mouse Genome Informatics
ht
    Pou4f3tm1Rsd/Pou4f3+
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
N
• at 2, 18 and 24 months of age, heterozygotes exhibit a comparable hearing to wild-type mice, with similar patterns of cochlear degeneration
• both heterozygous and wild-type mice display a ~30 dB hearing loss beginning at 18 months of age, outer hair cell degeneration and loss of spiral ganglion neurons in the basal turn

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Deafness, Autosomal Dominant 15; DFNA15 602459 J:57149