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Phenotypes Associated with This Genotype
Genotype
MGI:3688628
Allelic
Composition		 Nlgn1tm1Bros/Nlgn1tm1Bros
Nlgn2tm1Bros/Nlgn2tm1Bros
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn1tm1Bros mutation (1 available); any Nlgn1 mutation (66 available)
Nlgn2tm1Bros mutation (1 available); any Nlgn2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal parental behavior ( J:113647 )
• mice exhibit striking deficits in raising offspring

reproductive system
reduced fertility ( J:113647 )
• mice show drastically reduced reproduction rates

nervous system
abnormal CNS synaptic transmission ( J:113647 )
• in double nulls, high amplitude population of GABAergic and glycinergic sPSCs is decreased by <50%; numbers of sPSCs with lower amplitudes is moderately changed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory