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Phenotypes Associated with This Genotype
Genotype
MGI:3688527
Allelic
Composition
Aqp2tm1(AQP2)Suc/Aqp2+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp2tm1(AQP2)Suc mutation (0 available); any Aqp2 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• after dehydration, greater weight loss is seen in mutants (24.2%) than in mutants (13.9%)

homeostasis/metabolism
• before and after 24-hour water-deprivation period, osmolality of urine is reduced compared to wild-type (240 vs 2407 mOsm/kg H20 before deprivation, 1120 vs 3760 mOsm/kg H20 after deprivation)
• maximal osmolality after vasopressin injection is reduced compared to wild-type (644 vs 2938 mOsm/kg H20)

renal/urinary system
• before and after 24-hour water-deprivation period, osmolality of urine is reduced compared to wild-type (240 vs 2407 mOsm/kg H20 before deprivation, 1120 vs 3760 mOsm/kg H20 after deprivation)
• maximal osmolality after vasopressin injection is reduced compared to wild-type (644 vs 2938 mOsm/kg H20)
• urine volume is significantly increased compared to wild-type (5.5 ml/day vs 0.6 ml/day in wild-type)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
nephrogenic diabetes insipidus DOID:12387 OMIM:125800
OMIM:304800
J:113716


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory