Mouse Genome Informatics
ht
    Aqp2tm1(AQP2)Suc/Aqp2+
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• after dehydration, greater weight loss is seen in mutants (24.2%) than in mutants (13.9%)

homeostasis/metabolism
• before and after 24-hour water-deprivation period, osmolality of urine is reduced compared to wild-type (240 vs 2407 mOsm/kg H20 before deprivation, 1120 vs 3760 mOsm/kg H20 after deprivation)
• maximal osmolality after vasopressin injection is reduced compared to wild-type (644 vs 2938 mOsm/kg H20)

renal/urinary system
• before and after 24-hour water-deprivation period, osmolality of urine is reduced compared to wild-type (240 vs 2407 mOsm/kg H20 before deprivation, 1120 vs 3760 mOsm/kg H20 after deprivation)
• maximal osmolality after vasopressin injection is reduced compared to wild-type (644 vs 2938 mOsm/kg H20)
• urine volume is significantly increased compared to wild-type (5.5 ml/day vs 0.6 ml/day in wild-type)

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Insipidus, Nephrogenic, Autosomal 125800 J:113716