Analysis Tools
homeostasis/metabolism
 |
• serum levels of rT3 (reverse T3, competitive inhibitor of T3) are lower than in wild-type littermates
|
|
|
• T4 serum levels are lower than male wild-type littermates
|
|
|
• a 6-fold higher dose of L-T3 is needed to achieve full suppression of serum TSH levels in mutants vs wild-type than dose necessary to correct hypothyroidism induced by low iodine/0.15% propylthiouracil diet
|
|
|
• serum cholesterol levels are decreased compared to wild-type, indicating liver thyrotoxicosis
|
|
|
• glutathione S transferase alpha 2 (Gsta2) baseline level and following suppressive L-T3 dose is decreased vs wild-type
• L-T3 treatment does not change expression of D3 (Dio3) in mutants compared to a >2-fold increase in wild-type
|
|
|
• serum levels are higher than in wild-type, indicating liver thyrotoxicosis
|
|
|
• in 16 week old mice, baseline serum TSH concentration is significantly higher (51.5 mU/L) than in wild-type male littermates (20mU/L)
|
|
|
• after injection of L-T3, cerebrum in mutants has 2-10 times lower T3 content than wild-type at 4, 6, 16 and 20 hours, while serum and liver levels follow the same time course of disappearance in both genotypes
• at baseline, T3 content in cerebrum is 1.8 times lower than in wild-type
|
|
|
• mutants have higher serum T3 levels than male wild-type littermates
• baseline T3 content in mutant liver is 2.3-fold higher than in wild-type
|
|
|
• at baseline, level of D1(Dio1) activity is 3.1-fold higher in liver compared to wild-type
• at baseline, level of D2 (Dio2) activity is increased 10.6 fold
|
