Phenotypes Associated with This Genotype

Genotype
MGI:3688386

• Allelic Composition: Nr1h3^tm1Dgen/Nr1h3^tm1Dgen
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:112995 )

• high-cholesterol fed mutants infused with tauroursodeoxycholate to determine maximal secretory rates for biliary lipids exhibit slightly higher bile flows and a 200% increase in hepatobiliary excretion of phospholipids compared to wild-type but similar cholesterol secretion rates

abnormal cholesterol homeostasis ( J:112995 )

• cholesterol feeding increases hepatobiliary cholesterol (sterol ester) excretion to a higher level than in wild-type

liver/biliary system

abnormal hepatobiliary system physiology ( J:112995 )

• cholesterol feeding increases hepatobiliary cholesterol (sterol ester) excretion to a higher level than in wild-type