Mouse Genome Informatics
hm
    Btkxid/Btkxid
CBA/HN-Btkxid
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• spleens have only ~22% immunoglobulin-bearing cells compared to ~50% in controls (J:81429)
• Background Sensitivity: numbers (22%) are less than female mutants on CBA/HN * DBA/2N background (40%) (J:81429)
• incidence of B lymphocytes is slightly lower, but absolute population is not, compared to controls (J:81429)
• incidence of small lymphocytes is slightly lower, but absolute population is not, compared to controls (J:7981)
• cultured B cells show little response to B-cell mitogens LPS and poly I:C in comparison to wild-type cells (J:81429)
• Background Sensitivity: proliferative response in B cells from females is drastically lower than in cells from female mutants on CBA/HN * DBA/2N background (J:81429)
• incidence of pre-B cells is slightly reduced, but absolute population is comparable to controls (J:7981)
• number of nucleated spleen cells (~60 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen) (J:81429)
• Background Sensitivity: females have significantly less than females on the CBA/HN * DBA/2N background which have (~90 x 106/spleen) (J:81429)
• mice do not develop autoantibodies (anti-dsDNA or any IgG antinuclear autoantibodies) (J:125114)

hematopoietic system
• spleens have only ~22% immunoglobulin-bearing cells compared to ~50% in controls (J:81429)
• Background Sensitivity: numbers (22%) are less than female mutants on CBA/HN * DBA/2N background (40%) (J:81429)
• incidence of B lymphocytes is slightly lower, but absolute population is not, compared to controls (J:81429)
• incidence of small lymphocytes is slightly lower, but absolute population is not, compared to controls (J:7981)
• cultured B cells show little response to B-cell mitogens LPS and poly I:C in comparison to wild-type cells (J:81429)
• Background Sensitivity: proliferative response in B cells from females is drastically lower than in cells from female mutants on CBA/HN * DBA/2N background (J:81429)
• incidence of pre-B cells is slightly reduced, but absolute population is comparable to controls (J:7981)
• number of nucleated cells is higher in mutants than in controls (J:7981)
• number of nucleated spleen cells (~60 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen) (J:81429)
• Background Sensitivity: females have significantly less than females on the CBA/HN * DBA/2N background which have (~90 x 106/spleen) (J:81429)

Mouse Models of Human Disease
OMIM IDRef(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:81429