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Phenotypes Associated with This Genotype
Genotype
MGI:3687754
Allelic
Composition
Btkxid/Btkxid
Genetic
Background
CBA/HN-Btkxid
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btkxid mutation (2 available); any Btk mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• incidence of small lymphocytes is slightly lower, but absolute population is not, compared to controls
• spleens have only ~22% immunoglobulin-bearing cells compared to ~50% in controls
• Background Sensitivity: numbers (22%) are less than female mutants on CBA/HN * DBA/2N background (40%)
• incidence of B lymphocytes is slightly lower, but absolute population is not, compared to controls
• incidence of pre-B cells is slightly reduced, but absolute population is comparable to controls
• number of nucleated spleen cells (~60 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)
• Background Sensitivity: females have significantly less than females on the CBA/HN * DBA/2N background which have (~90 x 106/spleen)
• cultured B cells show little response to B-cell mitogens LPS and poly I:C in comparison to wild-type cells
• Background Sensitivity: proliferative response in B cells from females is drastically lower than in cells from female mutants on CBA/HN * DBA/2N background
• mice do not develop autoantibodies (anti-dsDNA or any IgG antinuclear autoantibodies)

hematopoietic system
• incidence of small lymphocytes is slightly lower, but absolute population is not, compared to controls
• number of nucleated cells is higher in mutants than in controls
• spleens have only ~22% immunoglobulin-bearing cells compared to ~50% in controls
• Background Sensitivity: numbers (22%) are less than female mutants on CBA/HN * DBA/2N background (40%)
• incidence of B lymphocytes is slightly lower, but absolute population is not, compared to controls
• incidence of pre-B cells is slightly reduced, but absolute population is comparable to controls
• number of nucleated spleen cells (~60 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)
• Background Sensitivity: females have significantly less than females on the CBA/HN * DBA/2N background which have (~90 x 106/spleen)
• cultured B cells show little response to B-cell mitogens LPS and poly I:C in comparison to wild-type cells
• Background Sensitivity: proliferative response in B cells from females is drastically lower than in cells from female mutants on CBA/HN * DBA/2N background

Mouse Models of Human Disease
OMIM ID Ref(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:81429


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory