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Phenotypes Associated with This Genotype
Genotype
MGI:3687752
Allelic
Composition
Btkxid/Y
Genetic
Background
involves: CBA/HN * DBA/2N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btkxid mutation (2 available); any Btk mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• spleens have only ~22% immunoglobulin-bearing cells compared to ~50% in controls
• number of nucleated spleen cells (~50 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)
• cultured B cells show little response to B-cell mitogens LPS and poly I:C in comparison to wild-type cells
• proliferative response occurs slightly later and is much lower in males than in females

immune system
• spleens have only ~22% immunoglobulin-bearing cells compared to ~50% in controls
• number of nucleated spleen cells (~50 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)
• cultured B cells show little response to B-cell mitogens LPS and poly I:C in comparison to wild-type cells
• proliferative response occurs slightly later and is much lower in males than in females

Mouse Models of Human Disease
OMIM ID Ref(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:81429


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory