Mouse Genome Informatics
ot
    Btkxid/Y
involves: CBA/HN * DBA/2N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• spleens have only ~22% immunoglobulin-bearing cells compared to ~50% in controls (J:81429)
• cultured B cells show little response to B-cell mitogens LPS and poly I:C in comparison to wild-type cells (J:81429)
• proliferative response occurs slightly later and is much lower in males than in females (J:81429)
• number of nucleated spleen cells (~50 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen) (J:81429)

immune system
• spleens have only ~22% immunoglobulin-bearing cells compared to ~50% in controls (J:81429)
• cultured B cells show little response to B-cell mitogens LPS and poly I:C in comparison to wild-type cells (J:81429)
• proliferative response occurs slightly later and is much lower in males than in females (J:81429)
• number of nucleated spleen cells (~50 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen) (J:81429)

Mouse Models of Human Disease
OMIM IDRef(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:81429