Mouse Genome Informatics
hm
    Btkxid/Btkxid
involves: CBA/HN * DBA/2N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• spleens from females have ~40% immunoglobulin-bearing cells compared to ~50% in controls (J:81429)
• Background Sensitivity: numbers are greater in female mutants on CBA * C57BL/6 background (40%) than females on CBA/HN background (22%) (J:81429)
• number of nucleated spleen cells (~90 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen) (J:81429)
• Background Sensitivity: females on the CBA * DBA/2J (~90 x 106/spleen) have significantly more nucleated spleen cells CBA/HN females (~60 x 106/spleen) (J:81429)
• spleen cells from unsensitized females cause 3-fold higher chromium release from H-2b antibody treated EL-4 tumor cells than splenocytes from males (J:81429)
• B cells show response to LPS and poly I:C similar to wild-type cells (J:81429)
• Background Sensitivity: proliferative response in B cells from females is much higher than in cells from female mutants on CBA/HN background (J:81429)

immune system
• spleens from females have ~40% immunoglobulin-bearing cells compared to ~50% in controls (J:81429)
• Background Sensitivity: numbers are greater in female mutants on CBA * C57BL/6 background (40%) than females on CBA/HN background (22%) (J:81429)
• number of nucleated spleen cells (~90 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen) (J:81429)
• Background Sensitivity: females on the CBA * DBA/2J (~90 x 106/spleen) have significantly more nucleated spleen cells CBA/HN females (~60 x 106/spleen) (J:81429)
• spleen cells from unsensitized females cause 3-fold higher chromium release from H-2b antibody treated EL-4 tumor cells than splenocytes from males (J:81429)
• B cells show response to LPS and poly I:C similar to wild-type cells (J:81429)
• Background Sensitivity: proliferative response in B cells from females is much higher than in cells from female mutants on CBA/HN background (J:81429)

Mouse Models of Human Disease
OMIM IDRef(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:81429