Mouse Genome Informatics
hm
    Btkxid/Btkxid
involves: CBA/HN * DBA/2N
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• spleens from females have ~40% immunoglobulin-bearing cells compared to ~50% in controls
• Background Sensitivity: numbers are greater in female mutants on CBA * C57BL/6 background (40%) than females on CBA/HN background (22%)
• number of nucleated spleen cells (~90 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)
• Background Sensitivity: females on the CBA * DBA/2J (~90 x 106/spleen) have significantly more nucleated spleen cells CBA/HN females (~60 x 106/spleen)
• spleen cells from unsensitized females cause 3-fold higher chromium release from H-2b antibody treated EL-4 tumor cells than splenocytes from males
• B cells show response to LPS and poly I:C similar to wild-type cells
• Background Sensitivity: proliferative response in B cells from females is much higher than in cells from female mutants on CBA/HN background

immune system
• spleens from females have ~40% immunoglobulin-bearing cells compared to ~50% in controls
• Background Sensitivity: numbers are greater in female mutants on CBA * C57BL/6 background (40%) than females on CBA/HN background (22%)
• number of nucleated spleen cells (~90 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)
• Background Sensitivity: females on the CBA * DBA/2J (~90 x 106/spleen) have significantly more nucleated spleen cells CBA/HN females (~60 x 106/spleen)
• spleen cells from unsensitized females cause 3-fold higher chromium release from H-2b antibody treated EL-4 tumor cells than splenocytes from males
• B cells show response to LPS and poly I:C similar to wild-type cells
• Background Sensitivity: proliferative response in B cells from females is much higher than in cells from female mutants on CBA/HN background

Mouse Models of Human Disease
OMIM IDRef(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:81429