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Phenotypes Associated with This Genotype
Genotype
MGI:3687751
Allelic
Composition
Btkxid/Btkxid
Genetic
Background
involves: CBA/HN * DBA/2N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btkxid mutation (2 available); any Btk mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• spleens from females have ~40% immunoglobulin-bearing cells compared to ~50% in controls
• Background Sensitivity: numbers are greater in female mutants on CBA * C57BL/6 background (40%) than females on CBA/HN background (22%)
• number of nucleated spleen cells (~90 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)
• Background Sensitivity: females on the CBA * DBA/2J (~90 x 106/spleen) have significantly more nucleated spleen cells CBA/HN females (~60 x 106/spleen)
• spleen cells from unsensitized females cause 3-fold higher chromium release from H-2b antibody treated EL-4 tumor cells than splenocytes from males
• B cells show response to LPS and poly I:C similar to wild-type cells
• Background Sensitivity: proliferative response in B cells from females is much higher than in cells from female mutants on CBA/HN background

immune system
• spleens from females have ~40% immunoglobulin-bearing cells compared to ~50% in controls
• Background Sensitivity: numbers are greater in female mutants on CBA * C57BL/6 background (40%) than females on CBA/HN background (22%)
• number of nucleated spleen cells (~90 x 106/spleen) is significantly lower than in controls (~120 x 106/spleen)
• Background Sensitivity: females on the CBA * DBA/2J (~90 x 106/spleen) have significantly more nucleated spleen cells CBA/HN females (~60 x 106/spleen)
• spleen cells from unsensitized females cause 3-fold higher chromium release from H-2b antibody treated EL-4 tumor cells than splenocytes from males
• B cells show response to LPS and poly I:C similar to wild-type cells
• Background Sensitivity: proliferative response in B cells from females is much higher than in cells from female mutants on CBA/HN background

Mouse Models of Human Disease
OMIM ID Ref(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:81429


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory