Phenotypes Associated with This Genotype

Genotype
MGI:3687636

• Allelic Composition: Reck^tm1Ito/Reck^tm1Ito
• Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:107674 )

• 2/3 die around E10.5 and none survive beyond E11.5

growth/size/body

decreased embryo size ( J:107674 )

embryo

decreased embryo size ( J:107674 )

abnormal vitelline vascular remodeling ( J:107674 )

• although vascular networks form in the yolk sac, their morphology resembles primitive vascular plexuses, suggesting defects in blood vessel maturation

cardiovascular system

abnormal vascular endothelial cell morphology ( J:107674 )

• vascular endothelial cells do not form tight and thin tubular structures

abnormal angiogenesis ( J:107674 )

• although vascular networks form in the embryo, their morphology resembles primitive vascular plexuses, suggesting defects in blood vessel maturation

internal hemorrhage ( J:107674 )

• frequently exhibit abdominal hemorrhage

cellular

abnormal basal lamina morphology ( J:107674 )

• exhibit almost complete loss of collagen fibrils and a discontinuous basal lamina surrounding the neural tube and blood vessels