Mouse Genome Informatics
cx
    Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0

involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• mice are diabetic; diabetes assessed by blood glucose measures >250 mg/dl on two consectutive measurements

endocrine/exocrine glands
• diabetic mice have nearly complete destruction of insulin producing cells
• thymus weight is variable, with some being normal and others having very low weight
• transgene expression in Rag1-deficient mice increases thymus cellularity and thymus weight almost to levels seen in NOD controls

immune system
• thymus weight is variable, with some being normal and others having very low weight
• transgene expression in Rag1-deficient mice increases thymus cellularity and thymus weight almost to levels seen in NOD controls
• mice have greater percentage of double-positive T cells (93%) in the thymus compared to other genotypes
• mice are lymphopenic compared to Rag1-sufficient transgenic mice and control NOD animals; number of lymphocytes in peripheral blood is lower than in transgenic Rag1-sufficient mice both in percentage of total white blood cell count and absolute lymphocyte count
• mice have lower percentage of single positive CD4+ T cells (3%) in the thymus compared to other genotypes
• mice develop spontaneous diabetes aged 4-32 weeks; diabetes develops only in mice with at least 1 copy of H-2g7 (incidence is 50% with homozygosity, 15% in heterozygotes); both sexes of transgenic mice are equally affected

hematopoietic system
• transgene expression in Rag1-deficient mice increases thymus cellularity and thymus weight almost to levels seen in NOD controls
• thymus weight is variable, with some being normal and others having very low weight
• mice have greater percentage of double-positive T cells (93%) in the thymus compared to other genotypes
• mice are lymphopenic compared to Rag1-sufficient transgenic mice and control NOD animals; number of lymphocytes in peripheral blood is lower than in transgenic Rag1-sufficient mice both in percentage of total white blood cell count and absolute lymphocyte count
• mice have lower percentage of single positive CD4+ T cells (3%) in the thymus compared to other genotypes

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:111874