Phenotypes Associated with This Genotype

Genotype
MGI:3686904

• Allelic Composition: Unc79^tm1Mnkm/Unc79^tm1Mnkm
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:111319 )

• majority die at P0 or the day after birth, however a few survive to P7

postnatal lethality, complete penetrance ( J:111319 )

• a few survive to P7

growth/size/body

decreased body weight ( J:111319 )

• pups surviving 2-4 days after birth gain no weight and those surviving to P6 or P7 are very thin

behavior/neurological

absent gastric milk in neonates ( J:111319 )

• over 90% of pups fail to nurse and no milk is found in the stomachs at P0 and the rest drink very little milk

weakness ( J:111319 )

• although newborns are active soon after birth, after half a day, they appear weak and movements decrease gradually

bradykinesia ( J:111319 )

• although newborns are active soon after birth, after half a day, they appear weak and movements decrease gradually