Phenotypes Associated with This Genotype

Genotype
MGI:3665286

• Allelic Composition: Tg(APPswe,PSEN1dE9)85Dbo/0
• Genetic Background: B6;C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:113199 , J:113200 , J:129021 )

• sparse deposits observed at 21 weeks of age, however, numerous deposits are observed at 45 and 60 weeks (J:113199)

• deposits are more extensive in females (J:113199)

• level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 20 weeks of age (J:113199)

• senile plaques detected by thioflavin S or the anti-amyloid beta antibody, 3D6, as early as 4 months of age (J:113200)

• plaques are restricted to cortex and hippocampus at time points up to 12 months of age (J:113200)

• plaques increase in number and size over time (J:113200)

• exhibits an overall increase in soluble and insoluble amyloid beta peptide 40 and 42 between 4 and 12 months (J:113200)

• insoluble amyloid beta42 is increased 2-fold in cerebrum of sucrose-fed mice as compared to water-fed control (J:129021)

• total amyloid beta levels are increased by 3.6 fold in sucrose fed mice (J:129021)

• amyloid beta deposition is increased by 2.9-fold as determined by immunohistochemical and morphometric analysis in sucrose-fed mice (J:129021)

cerebral amyloid angiopathy ( J:113200 )

• exhibits progressive increase in cerebral amyloid angiopathy as early as 6 months

• amyloid deposition is observed in leptomeningeal vasculature

behavior/neurological

abnormal spatial learning ( J:129021 )

• transgenic mice fed sucrose water failed to learn Morris water maze test after 5 days of training

• water-fed transgenic mice retained some learning ability over 5 day test period, but did not perform as well in the water maze test as non-transgenic controls

increased fluid intake ( J:129021 )

• mice fed sucrose water exhibited increased water consumption

homeostasis/metabolism

amyloidosis ( J:129021 )

amyloid beta deposits ( J:113199 , J:113200 , J:129021 )

• sparse deposits observed at 21 weeks of age, however, numerous deposits are observed at 45 and 60 weeks (J:113199)

• deposits are more extensive in females (J:113199)

• level of brain amyloid beta peptide 42 is predominant over 40; levels increase dramatically after 20 weeks of age (J:113199)

• senile plaques detected by thioflavin S or the anti-amyloid beta antibody, 3D6, as early as 4 months of age (J:113200)

• plaques are restricted to cortex and hippocampus at time points up to 12 months of age (J:113200)

• plaques increase in number and size over time (J:113200)

• exhibits an overall increase in soluble and insoluble amyloid beta peptide 40 and 42 between 4 and 12 months (J:113200)

• insoluble amyloid beta42 is increased 2-fold in cerebrum of sucrose-fed mice as compared to water-fed control (J:129021)

• total amyloid beta levels are increased by 3.6 fold in sucrose fed mice (J:129021)

• amyloid beta deposition is increased by 2.9-fold as determined by immunohistochemical and morphometric analysis in sucrose-fed mice (J:129021)

cerebral amyloid angiopathy ( J:113200 )

• exhibits progressive increase in cerebral amyloid angiopathy as early as 6 months

• amyloid deposition is observed in leptomeningeal vasculature

increased circulating insulin level ( J:129021 )

• fasting plasma insulin levels are increased 3 fold in mice fed sucrose water as compared to water-fed control

increased circulating cholesterol level ( J:129021 )

• total cholesterol, but not HDL, levels are increased 30% in mice fed sucrose water as compared to water-fed control

increased circulating triglyceride level ( J:113199 )

• elevated plasma triglyceride levels observed in females at 15 weeks of age

impaired glucose tolerance ( J:129021 )

• mice fed sucrose water displayed an impaired glucose tolerance as compared to water-fed control

cardiovascular system

blood vessel congestion ( J:113200 )

growth/size/body

increased body weight ( J:129021 )

• mice fed sucrose water consistently gained weight over study time period (2 months- 8 months)

• sucrose-fed mice increased body weight by 17% over water-fed controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:113199
Alzheimer's disease 3		DOID:0110042	OMIM:607822	J:113199