About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3665237
Allelic
Composition
Frem1tm1Ksek/Frem1tm1Ksek
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frem1tm1Ksek mutation (1 available); any Frem1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Phenotypes and electron microscopy of Frem1tm1Ksek/Frem1tm1Ksek mice

limbs/digits/tail

vision/eye

renal/urinary system

integument
• exhibit subepidermal blistering occurring between the lamina densa of the basement membrane and the underlying dermis at E14.5

skeleton
• mutants exhibit complete fusion of the posterior frontal suture at postnatal day 28 compared to day 45 in controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Fraser syndrome DOID:0090001 OMIM:PS219000
J:111788


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/13/2019
MGI 6.13
The Jackson Laboratory