Phenotypes Associated with This Genotype

Genotype
MGI:3665139

• Allelic Composition: Ccr2^tm1Brv/Ccr2^tm1Brv
• Genetic Background: involves: 129S1/Sv * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ccr2^tm1Brv/Ccr2^tm1Brv mice are unable to clear Listeria monocytogenes infection

immune system

impaired macrophage chemotaxis ( J:111517 )

• 72 hours after peritoneal thioglycollate injection, number of macrophages recovered in peritoneal exudates is one eighth that of wild-type

increased eosinophil cell number ( J:111517 )

• number of recruited eosinophils is increased in mutants vs wild-type in response to thioglycollate

abnormal spleen morphology ( J:111517 )

• severe multifocal inflammation and necrosis is also observed in spleens of mutants following infection

enlarged spleen ( J:111517 )

• at autopsy after bacterial infection, spleens are enlarged and normal in color while wild-type are normal size but mottled in appearance

liver inflammation ( J:111517 )

• severe, multifocal inflammation is observed in mutants

increased susceptibility to bacterial infection ( J:111517 )

• mutants are unable to clear Listeria monocytogenes infection

• bacterial titers in spleen, liver and lungs of mutants are 3-7 log-fold higher than wild-type 5 days post infection

hematopoietic system

impaired macrophage chemotaxis ( J:111517 )

• 72 hours after peritoneal thioglycollate injection, number of macrophages recovered in peritoneal exudates is one eighth that of wild-type

increased eosinophil cell number ( J:111517 )

• number of recruited eosinophils is increased in mutants vs wild-type in response to thioglycollate

abnormal spleen morphology ( J:111517 )

• severe multifocal inflammation and necrosis is also observed in spleens of mutants following infection

enlarged spleen ( J:111517 )

• at autopsy after bacterial infection, spleens are enlarged and normal in color while wild-type are normal size but mottled in appearance

liver/biliary system

multifocal hepatic necrosis ( J:111517 )

• necrotic lesions are observed after Listeria infection; lesions have central core of coagulative necrosis containing neutrophils, cellular debris and a rim of necrotic hepatocytes with abundant intracellular bacteria

enlarged liver ( J:111517 )

• at autopsy after bacterial infection, livers are enlarged and normal in color while wild-type are normal size but mottled in appearance

liver inflammation ( J:111517 )

• severe, multifocal inflammation is observed in mutants

cellular

multifocal hepatic necrosis ( J:111517 )

• necrotic lesions are observed after Listeria infection; lesions have central core of coagulative necrosis containing neutrophils, cellular debris and a rim of necrotic hepatocytes with abundant intracellular bacteria

impaired macrophage chemotaxis ( J:111517 )

• 72 hours after peritoneal thioglycollate injection, number of macrophages recovered in peritoneal exudates is one eighth that of wild-type

growth/size/body

enlarged liver ( J:111517 )

• at autopsy after bacterial infection, livers are enlarged and normal in color while wild-type are normal size but mottled in appearance

enlarged spleen ( J:111517 )

• at autopsy after bacterial infection, spleens are enlarged and normal in color while wild-type are normal size but mottled in appearance