Mouse Genome Informatics
hm
    Ncoa1tm1.1Hkaw/Ncoa1tm1.1Hkaw
B6.Cg-Ncoa1tm1.1Hkaw
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• mice show slight increase in body weight with increasing age vs wild-type as result of obesity

homeostasis/metabolism
• serum levels are elevated in male mutants
• serum levels are elevated in female mutants
• serum levels are somewhat upregulated in mutants but increase is not statistically significant
• serum levels of this marker of bone formation are increased in mutants compared to wild-type littermates
• urinary deoxypyridinoline, a marker for bone resorption, is higher in mutants vs wild-type littermates

endocrine/exocrine glands
• slight testicular hypoplasia of testis (~20%) is observed in male knockouts at 24 weeks of age (J:111490)

renal/urinary system
• urinary deoxypyridinoline, a marker for bone resorption, is higher in mutants vs wild-type littermates

reproductive system
• slight testicular hypoplasia of testis (~20%) is observed in male knockouts at 24 weeks of age (J:111490)

skeleton
• at 24 weeks of age, an ~10% reduction in bone mineral density of long bones in male and female Ncoa1tm1.1Haw homozygotes compared to littermates
• in femora of mutants, there is ~35-40% lower bone mineral content (BMC) and bone mineral density (BMD) of trabecular bones; cortical bones are not affected
• mice show a state of high-turnover osteopenia (higher increase in parameters of bone resorption vs parameters of bone formation)
• at 24 weeks, bone volume (bone volume/tissue volume) is decreased by 30-40% compared to wild-type
• indicated by high turn-over osteopenia at 24 weeks
• parameters for bone formation and bone resorption are significantly higher in mutants; bone formation parameters are increased ~30-60% in mutants
• bone resorption parameters are increased by ~60-80% in mutants

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:111490