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Phenotypes Associated with This Genotype
Genotype
MGI:3663892
Allelic
Composition
Metap2tm1.2Ccr/Metap2tm1.2Ccr
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Metap2tm1.2Ccr mutation (0 available); any Metap2 mutation (32 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• develop past gastrulation and survive until E9.5

embryo
• embryos become necrotic around E9.5
• 6 of 7 E9.5 embryos are smaller than controls but show developed anterior-posterior patterning with head, trunk, and tail region

growth/size/body
• 6 of 7 E9.5 embryos are smaller than controls but show developed anterior-posterior patterning with head, trunk, and tail region

cardiovascular system
• embryos form an initial vascular network, especially in the brain, however it is less complex than in controls

cellular
• embryos become necrotic around E9.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory