Phenotypes Associated with This Genotype

Genotype
MGI:3663891

• Allelic Composition: Metap2^tm1.2Ccr/Metap2^tm1.2Ccr
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:111701 )

• lethality around E8.5

embryo

failure to gastrulate ( J:111701 )

• fail to start gastrulation

embryonic growth arrest ( J:111701 )

• at E7.5, embryos appear to be in the egg-cylinder stage instead of the midgastrulation stage and do not develop beyond the egg-cylinder stage by E8.5

decreased embryo size ( J:111701 )

• consistently reduced in size by E6.5

absent mesoderm ( J:111701 )

• at E7.5, lack a distinct mesoderm, however show normal development of ectoplacental cone, maternal-embryonic interface, ectoderm and endoderm

growth/size/body

decreased embryo size ( J:111701 )

• consistently reduced in size by E6.5

cellular

decreased cell proliferation ( J:111701 )

• E7.5 embryos show decreased cell proliferation