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Phenotypes Associated with This Genotype
Genotype
MGI:3663749
Allelic
Composition
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(MAPT)8cPdav/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm1(EGFP)Klt mutation (3 available); any Mapt mutation (393 available)
Tg(MAPT)8cPdav mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• phosphorylated tau accumulates in neuronal cell bodies and dendrites of the hippocampus and neocortex as early as 3 months of age (J:84638)
• in particular, accumulations occur in entorhinal cortex, ventromedial hypothalamus, medial septum and the nucleus of the horizontal limb of the diagonal band (J:84638)
• increase in tau phosphorylation occurs at serine 202, threonine 231 and serine 235 as determined by immunoblot (J:84638)
• tau aggregates in the proximal dendrites have an average width of 15 nm and are not densely packed (J:84638)
• insoluble tau is present in both 2 and 9 month old mice (J:84638)
• paired helical filaments are observed in 9, 12 and 14 month old mice (J:84638)
• paired helical filaments are observed in 9, 12 and 14 month old mice (J:84638)
• phosphorylated tau accumulates in neuronal cell bodies and dendrites of the hippocampus and neocortex as early as 3 months of age (J:84638)
• in particular, accumulations occur in entorhinal cortex, ventromedial hypothalamus, medial septum and the nucleus of the horizontal limb of the diagonal band (J:84638)
• increase in tau phosphorylation occurs at serine 202, threonine 231 and serine 235 as determined by immunoblot (J:84638)
• tau aggregates in the proximal dendrites have an average width of 15 nm and are not densely packed (J:84638)
• insoluble tau is present in both 2 and 9 month old mice (J:84638)
• cells in the cortex and hippocampus appear irregularly shaped, often with distorted processes in 13 month old mice (J:84638)
• cells in the cortex and hippocampus appear irregularly shaped, often with distorted processes in 13 month old mice (J:84638)

hematopoietic system
• splenic red pulp is largely obliterated (J:174270)
• splenic red pulp is largely obliterated (J:174270)
• splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles (J:174270)
• splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles (J:174270)

immune system
• splenic red pulp is largely obliterated (J:174270)
• splenic red pulp is largely obliterated (J:174270)
• splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles (J:174270)
• splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles (J:174270)

renal/urinary system
• kidney glomeruli are dilated probably due to obstruction from the amyloid in the lumen or walls of medullary tubules especially in the papilla (J:174270)
• kidney glomeruli are dilated probably due to obstruction from the amyloid in the lumen or walls of medullary tubules especially in the papilla (J:174270)

tumorigenesis
• malignant lymphoma in the spleen and lymph nodes are seen in some mutants (J:174270)
• megakaryocytes are numerous is some spleens, suggesting a relation to megakaryocytic leukemia (J:174270)
• malignant lymphoma in the spleen and lymph nodes are seen in some mutants (J:174270)
• megakaryocytes are numerous is some spleens, suggesting a relation to megakaryocytic leukemia (J:174270)
• splenic architecture is replaced by proliferated immature mononuclear cells arranged in follicular aggregates indicating follicular lymphoma (J:174270)
• splenic architecture is replaced by proliferated immature mononuclear cells arranged in follicular aggregates indicating follicular lymphoma (J:174270)

homeostasis/metabolism
• some mutants older than 18 months exhibit amyloid deposits in the spleen, kidneys, liver, ovary and/or heart (J:174270)
• amyloid is deposited concentrically in the perifollicular sheath, partly or completely encircling the follicles in the spleen (J:174270)
• in the liver, amyloid deposit is in the walls of sinusoids or central veins (J:174270)
• in the kidney, amyloid deposits are seen in the glomeruli (J:174270)
• amyloid deposits in the heart are not composed of amyloid-beta peptide, but rather amyloid A (J:174270)
• some mutants older than 18 months exhibit amyloid deposits in the spleen, kidneys, liver, ovary and/or heart (J:174270)
• amyloid is deposited concentrically in the perifollicular sheath, partly or completely encircling the follicles in the spleen (J:174270)
• in the liver, amyloid deposit is in the walls of sinusoids or central veins (J:174270)
• in the kidney, amyloid deposits are seen in the glomeruli (J:174270)
• amyloid deposits in the heart are not composed of amyloid-beta peptide, but rather amyloid A (J:174270)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:84638 , J:174270


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory