Mouse Genome Informatics
cx
    Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(MAPT)8cPdav/?

involves: 129S4/SvJae * C57BL/6 * Swiss Webster
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• phosphorylated tau accumulates in neuronal cell bodies and dendrites of the hippocampus and neocortex as early as 3 months of age
• in particular, accumulations occur in entorhinal cortex, ventromedial hypothalamus, medial septum and the nucleus of the horizontal limb of the diagonal band
• increase in tau phosphorylation occurs at serine 202, threonine 231 and serine 235 as determined by immunoblot
• tau aggregates in the proximal dendrites have an average width of 15 nm and are not densely packed
• insoluble tau is present in both 2 and 9 month old mice
• paired helical filaments are observed in 9, 12 and 14 month old mice
• cells in the cortex and hippocampus appear irregularly shaped, often with distorted processes in 13 month old mice

hematopoietic system
• splenic red pulp is largely obliterated
• splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles

immune system
• splenic red pulp is largely obliterated
• splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles

other phenotype
• some mutants older than 18 months exhibit amyloid deposits in the spleen, kidneys, liver, ovary and/or heart
• amyloid is deposited concentrically in the perifollicular sheath, partly or completely encircling the follicles in the spleen
• in the liver, amyloid deposit is in the walls of sinusoids or central veins
• in the kidney, amyloid deposits are seen in the glomeruli
• amyloid deposits in the heart are not composed of amyloid-beta peptide, but rather amyloid A

renal/urinary system
• kidney glomeruli are dilated probably due to obstruction from the amyloid in the lumen or walls of medullary tubules especially in the papilla

tumorigenesis
• malignant lymphoma in the spleen and lymph nodes are seen in some mutants
• megakaryocytes are numerous is some spleens, suggesting a relation to megakaryocytic leukemia
• splenic architecture is replaced by proliferated immature mononuclear cells arranged in follicular aggregates indicating follicular lymphoma

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:84638 , J:174270