Mouse Genome Informatics
cx
    Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0

involves: C3H/HeJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
N
• no differences in neuron number in cingulate cortex relative to wild-type (J:100961)
• amyloid beta deposits found in cortex and hippocampus tissue from 9 and 12 month old mice and increase in number between 10 ans 12 months of age (J:43788)
• amyloid beta peptides AB1-40 and AB1-42 are codeposited (J:43788)
• ratio of amyloid beta peptide 40:42 is 1.75:1 (J:87691)
• exhibits a 50% increase in amyloid beta peptide 42 (J:87691)
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old double transgenic mice; deposits are most evident in gray matter of cingulate and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)
• associated with dystropic neuritis in cortex and hippocampus
• dystrophic neuritis associated with reactive gliosis in cortex and hippocampus
• neurons in cingulate cortex display 3-fold elevation in phosphorylated tumor suppressor protein (pRb) and activated caspase-3 relative to wild-type neurons

homeostasis/metabolism
• amyloid beta deposits found in cortex and hippocampus tissue from 9 and 12 month old mice and increase in number between 10 ans 12 months of age (J:43788)
• amyloid beta peptides AB1-40 and AB1-42 are codeposited (J:43788)
• ratio of amyloid beta peptide 40:42 is 1.75:1 (J:87691)
• exhibits a 50% increase in amyloid beta peptide 42 (J:87691)
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old double transgenic mice; deposits are most evident in gray matter of cingulate and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease 3 607822 J:43788
Alzheimer Disease 4 606889 J:43788
Alzheimer Disease; AD 104300 J:43788