Phenotypes for Htr2a Slc6a4 MGI:3663444 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Htr2a^tm1Grch/Htr2a^tm2Grch Slc6a4^tm1(cre)Grch/Slc6a4⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2a^tm1Grch mutation (0 available); any Htr2a mutation (42 available)
Htr2a^tm2Grch mutation (0 available); any Htr2a mutation (42 available)
Slc6a4^tm1(cre)Grch mutation (0 available); any Slc6a4 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal anxiety-related response ( J:110958 )

• reduced inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors in the dark-light choice test

• selective restoration of 5HT2AR signaling to the thalamus did not normalized conflict anxiety behaviors

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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