Phenotypes Associated with This Genotype

Genotype
MGI:3663440

• Allelic Composition: Htr2a^tm1Grch/Htr2a^tm2Grch
• Genetic Background: 129S6/SvEv-Htr2a^tm1Grch Htr2a^tm2Grch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal anxiety-related response ( J:110958 )

• reduced inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors

• home cage activity did not differ

• motor coordination, strength, and sensory processing were unimpaired

• baseline concentrations and the rise in corticosterone release following anxiety tests were comparable

• cell number, mantel thickness, barrel field formation, or the expression of GABA containing neuronal markers are normal

decreased anxiety-related response ( J:110958 )

• explored the lit compartment to a greater extent in the dark-light choice test

• explored the riskier portions of the elevated plus-maze to a greater extent

• exhibited a shorter latency to begin feeding in a novel environment

increased vertical activity ( J:110958 )

• in open field