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Phenotypes Associated with This Genotype
Genotype
MGI:3656138
Allelic
Composition
Ahrtm1Gonz/Ahrtm1Gonz
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahrtm1Gonz mutation (1 available); any Ahr mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• interperitoneal injection of 2000 ug/kg TCDD fails to induce thymic cortical atrophy, changes in thymic lymphocyte numbers, increased hepatic lipid accumulation, or increases in liver weight all of which are seen in wild-type and heterozygous mice injected with 200 ug/kg TCDD
• interperitoneal injection of 2000 ug/kg TCDD but not 200 ug/kg does induce a significant increase in lymphocyte and marcophage infiltrates and perivascular cuffs in the lung which are seen in wild-type and heterozygous mice exposed to200 ug/kg TCDD

reproductive system
N
• mammary gland development is normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory