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Phenotypes Associated with This Genotype
Genotype
MGI:3655854
Allelic
Composition
Krt1Mhdadsk12/Krt1+
Genetic
Background
C3HeB/FeJ-Krt1Mhdadsk12
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt1Mhdadsk12 mutation (1 available); any Krt1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• increased epidermal pigment in the tips of the rete ridges and within the eccrine ducts
• excessive pigmentation in heterozygous animals, most notably in volar pads, intervolar pad scales, and the digit tips

integument
• observed in footpads
• thick, brown hyperkeratotic plaques are seen on the footpads of adults
• observed in footpads
• immediately after birth, animals develop blisters and erosions at the sites of friction
• this phenotype diminishes with the onset of hair growth
• by two weeks of age, blistering and erosions are replaced by scaling
• increased epidermal pigment in the tips of the rete ridges and within the eccrine ducts

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
epidermolytic hyperkeratosis DOID:4603 OMIM:113800
J:108758


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory