Mouse Genome Informatics
hm
    Lepob/Lepob
D2.B6-Lepob
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size/body

homeostasis/metabolism
• at 3 months of age, males are hyperglycemic with blood glucose levels of ~574 mg/dl; females have levels of ~388 mg/dl
• some mutant DBA/2J mice have high insulin levels compared to controls

endocrine/exocrine glands
• islets of mutants with low insulin levels are abnormal in appearance, being found in clusters of 1-4 cells, scattered within the ductal epithelium
• mutants with low insulin secretion have a low number of insulin-secreting cells compared to controls or high-insulin secreting mutants
• there is a 5-fold increase in number of insulin-secreting cells per islet in obese mice with high insulin secretion

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:78850