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Phenotypes Associated with This Genotype
Genotype
MGI:3655835
Allelic
Composition
Lepob/Lepob
Genetic
Background
D2.B6-Lepob
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepob mutation (6 available); any Lep mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

homeostasis/metabolism
• at 3 months of age, males are hyperglycemic with blood glucose levels of ~574 mg/dl; females have levels of ~388 mg/dl (J:78850)
• at 3 months of age, males are hyperglycemic with blood glucose levels of ~574 mg/dl; females have levels of ~388 mg/dl (J:78850)
• some mutant DBA/2J mice have high insulin levels compared to controls (J:78850)
• some mutant DBA/2J mice have high insulin levels compared to controls (J:78850)

endocrine/exocrine glands
• islets of mutants with low insulin levels are abnormal in appearance, being found in clusters of 1-4 cells, scattered within the ductal epithelium (J:78850)
• islets of mutants with low insulin levels are abnormal in appearance, being found in clusters of 1-4 cells, scattered within the ductal epithelium (J:78850)
• mutants with low insulin secretion have a low number of insulin-secreting cells compared to controls or high-insulin secreting mutants (J:78850)
• mutants with low insulin secretion have a low number of insulin-secreting cells compared to controls or high-insulin secreting mutants (J:78850)
• there is a 5-fold increase in number of insulin-secreting cells per islet in obese mice with high insulin secretion (J:78850)
• there is a 5-fold increase in number of insulin-secreting cells per islet in obese mice with high insulin secretion (J:78850)

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:78850


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory