Phenotypes Associated with This Genotype

Genotype
MGI:3655082

• Allelic Composition: Foxk1^tm1Djg/Foxk1^tm1Djg
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:62225 )

• year old mice are 60% the size of age matched controls

muscle

abnormal myogenesis ( J:81688 )

abnormal muscle precursor cell morphology ( J:81688 )

• pool of myogenic progenitor cells in skeletal muscle is reduced by 71%

impaired skeletal muscle regeneration ( J:62225 )

• repair of skeletal muscle damaged by cardiotoxin injection is impaired

• eventual regeneration is accompanied by extensive replacement of muscle with fat

cellular

abnormal cell cycle ( J:81688 )

• cell cycle progression is disrupted

• increased numbers of G₀ and G₁ cells

• decreased numbers of S and G₂/M cells