Phenotypes Associated with This Genotype

Genotype
MGI:3654105

• Allelic Composition: Nup98^tm1Bmaf/Nup98⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:110907 )

• specific T cell proliferation is significantly reduced in response to immunization of with ovalbumin and M. tuberculosis-containing CFA

increased T cell proliferation ( J:110907 )

• T cell proliferation in vitro in response to anti-CD3 is enhanced in cells from mutants compared to wild-type

decreased B cell number ( J:110907 )

• there is a decrease in frequency of B cells observed in the spleen

decreased CD4-positive, alpha-beta T cell number ( J:110907 )

• there is a significant decrease in numbers of CD4+ T cells and TCRab+ T cells in the thymus of heterozygotes

• lower numbers of CD4+ T cells are present compared to wild-type mice; the effect is more significant in the secondary response to the antigen

decreased IgG level ( J:110907 )

• a small but significant reduction in the serum level of Ig levels produced by B cells

decreased IgG1 level ( J:110907 )

• IgG1 levels are reduced but IgA and IgM levels are similar to wild-type

abnormal level of surface class I molecules ( J:110907 )

• levels of MHC class I are decreased in macrophages and dendritic cells from the thymi and spleens of heterozygous mice

• Ifng-stimulated induction of MHC I and II is impaired in macrophages isolated from heterozygous mice; IFNalpha-induction of MHC I is also impaired

abnormal level of surface class II molecules ( J:110907 )

• levels are reduced in dendritic cells from the spleen and thymus

abnormal MHC II cell surface expression on macrophages ( J:110907 )

• level of MHC class II are reduced in macrophages from the spleen and thymus of heterozygotes

hematopoietic system

decreased T cell proliferation ( J:110907 )

• specific T cell proliferation is significantly reduced in response to immunization of with ovalbumin and M. tuberculosis-containing CFA

increased T cell proliferation ( J:110907 )

• T cell proliferation in vitro in response to anti-CD3 is enhanced in cells from mutants compared to wild-type

decreased B cell number ( J:110907 )

• there is a decrease in frequency of B cells observed in the spleen

decreased CD4-positive, alpha-beta T cell number ( J:110907 )

• there is a significant decrease in numbers of CD4+ T cells and TCRab+ T cells in the thymus of heterozygotes

• lower numbers of CD4+ T cells are present compared to wild-type mice; the effect is more significant in the secondary response to the antigen

decreased IgG level ( J:110907 )

• a small but significant reduction in the serum level of Ig levels produced by B cells

decreased IgG1 level ( J:110907 )

• IgG1 levels are reduced but IgA and IgM levels are similar to wild-type

abnormal MHC II cell surface expression on macrophages ( J:110907 )

• level of MHC class II are reduced in macrophages from the spleen and thymus of heterozygotes

cellular

decreased T cell proliferation ( J:110907 )

• specific T cell proliferation is significantly reduced in response to immunization of with ovalbumin and M. tuberculosis-containing CFA

increased T cell proliferation ( J:110907 )

• T cell proliferation in vitro in response to anti-CD3 is enhanced in cells from mutants compared to wild-type