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Phenotypes Associated with This Genotype
Genotype
MGI:3653875
Allelic
Composition
Kcnd2tm1Jmn/Kcnd2tm1Jmn
Genetic
Background
FVB.129-Kcnd2tm1Jmn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnd2tm1Jmn mutation (1 available); any Kcnd2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• after formalin injection, mutants exhibit an elevated second phase response compared to wild-type but lack a peak second phase

nervous system
• ventricular myocytes lack a fast component of recovery to their fast inactivating/recovering transient outward current
• mutant myocytes are not sensitive to heterpodatoxin, as transient outward currents are not reduced compared to the effect in wild-type


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory