Phenotypes Associated with This Genotype

Genotype
MGI:3653874

• Allelic Composition: Kcnd2^tm1Jmn/Kcnd2^tm1Jmn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hyperresponsive to tactile stimuli ( J:110968 )

• mutants show enhanced sensitivity to mechanical stimuli: thresholds to von Frey filament stimuli and noxious pressure on the tail are reduced relative to wild-type

decreased thermal nociceptive threshold ( J:110968 )

• latencies to withdrawal are shorter in the hot plate test compared to wild-type

nervous system

abnormal neuron morphology ( J:110968 )

• laminaI/II dorsal horn neurons in the mutant spinal cord show decreased excitability in slices compared to wild-type

abnormal channel response ( J:110968 )

• amplitude of A-type potassium currents in cultured neurons from mutants are decreased by 56% compared to wild-type

• recovery of A-type currents from inactiviation is slower in neurons from mutants