About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3653642
Allelic
Composition
Als2tm1Hay/Als2tm1Hay
Genetic
Background
involves: 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Als2tm1Hay mutation (0 available); any Als2 mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 15 months of age, open-field activity tests reveal that homozygotes are hypoactive; this is true for 3 month old mice as well and did not worsen with age

nervous system
• measures of neuronal size reveal that mutant neurons have smaller cell bodies and axons of diminished caliber but these did not reach significance except in the motor cortex
• receptor trafficking is disturbed in homozygotes; ability to support Rab5-dependent endosome fusion is impaired
• in culture, neurons show abnormal endosomal receptor (TrkB and IGF1R) trafficking
• upper motorneurons in layer V of the motor cortex have significantly smaller cell bodies (7% reduction in mean cell area) at 12 months of age compared to controls;


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory