Phenotypes Associated with This Genotype

Genotype
MGI:3653184

• Allelic Composition: Hnf4a^tm1.1Gonz/Hnf4a^tm1.1Gonz; Tg(Alb1-cre)1Dlr/0
• Genetic Background: involves: 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:67396 )

• by 8 weeks of age mortality is over 70%

growth/size/body

weight loss ( J:67396 )

• at 5 weeks of age, mice begin to lose weight

enlarged liver ( J:67396 )

homeostasis/metabolism

decreased circulating cholesterol level ( J:67396 )

• sera levels are dramatically reduced relative to controls

decreased circulating HDL cholesterol level ( J:67396 )

• sera levels are dramatically reduced relative to controls

decreased circulating triglyceride level ( J:67396 )

• sera levels are dramatically reduced relative to controls

liver/biliary system

abnormal liver morphology ( J:67396 )

• liver has a gray, mottled appearance; marked pathological lesions are evident

enlarged liver ( J:67396 )

abnormal hepatocyte morphology ( J:67396 )

• hepatocytes are markedly vacuolated with material in vacuoles staining positive for fat; centrolobular hepatocytes are invariably hypertrophic with pale eosinophilic cytoplasmic inclusions

• most hepatocytes have large mitochondria and abundant lipid droplets while others both had lipid droplets and abundant glycogen-like material

abnormal hepatocyte mitochondrial morphology ( J:67396 )

cellular

abnormal hepatocyte mitochondrial morphology ( J:67396 )