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Phenotypes Associated with This Genotype
Genotype
MGI:3652841
Allelic
Composition
Arhgap5tm1Jset/Arhgap5tm1Jset
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap5tm1Jset mutation (0 available); any Arhgap5 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die immediately after birth

growth/size/body
• 30% reduction in body size

nervous system
• severe reduction in the major midline forebrain crossing tracts (corpus callosum and anterior commissure)
• thinner cortex associated with partial loss of cortical axon tracts

respiratory system
• lungs fail to inflate properly at birth

hematopoietic system
• seen at birth

immune system
• seen at birth

adipose tissue
• newborns exhibit a reduction in subcutaneous fat in dermal tissue
• MEF cultures are significantly impaired in their ability to undergo adipogenic conversion and to differentiate into adipocytes and instead undergo myogenic differentiation

integument
• newborns exhibit a reduction in subcutaneous fat in dermal tissue

endocrine/exocrine glands
• seen at birth


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory