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Phenotypes Associated with This Genotype
Genotype
MGI:3652589
Allelic
Composition
Thoc1tm1Dwg/Thoc1tm1Dwg
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thoc1tm1Dwg mutation (0 available); any Thoc1 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no post-implantation homozygotes are detected at E8.5-11.5, however, expected Mendelian numbers of homozygous blastocysts are recovered at E3.5 suggesting lethality around the time of implantation

embryo
• after E3.5, null embryos show increased cellular apoptosis and loss of cell viability
• most embryos fail to hatch from the zona pellucida
• null embryos in culture cannot produce viable blastocyst outgrowths as cells of the inner cell mass are lacking

cellular
• after E3.5, null embryos show increased cellular apoptosis and loss of cell viability


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory