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Phenotypes Associated with This Genotype
Genotype
MGI:3652375
Allelic
Composition
Fxntm1Mkn/Fxntm1Pand
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fxntm1Mkn mutation (13 available); any Fxn mutation (30 available)
Fxntm1Pand mutation (2 available); any Fxn mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 2/13 mice died during the course of the experiment; 1 of these died at about 12 months of age

homeostasis/metabolism
• the mouse that died at about 12 months of age had 3-fold higher iron levels in the heart than littermates (1168 ug vs 399 ug)

cardiovascular system
• the mouse that died at about 12 months of age had 3-fold higher iron levels in the heart than littermates (1168 ug vs 399 ug)
• the mouse that died at ~ 12 months showed prominent heart fibrosis

immune system
• inflammatory arachidonic metabolites are elevated in cerebellum

nervous system
• inflammatory arachidonic metabolites are elevated in cerebellum

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Friedreich ataxia DOID:12705 OMIM:229300
OMIM:601992
J:216422


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory