Phenotypes Associated with This Genotype

Genotype
MGI:3641418

• Allelic Composition: Dlk1^tm1Hsul/Dlk1^tm1Hsul
• Genetic Background: either: (involves: 129 * BALB/c) or (involves: 129 * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:77909 )

• approximately 50% of mutant were dead within 2 days of birth

reproductive system

decreased litter size ( J:77909 )

growth/size/body

postnatal growth retardation ( J:77909 )

• growth retardation with moderately larger fat pad mass in mutant mice at 15 weeks of age

fetal growth retardation ( J:77909 )

• smaller than wild-type at E18.5

enlarged liver ( J:77909 )

• when fed a high fat diet

skeleton

asymmetric rib joints ( J:77909 )

• found in embryos and postnatal dead mice

rib fusion ( J:77909 )

• found in embryos and postnatal dead mice

vision/eye

narrow eye opening ( J:77909 )

• Background Sensitivity: seen only in BALB/cJ background but not in C57BL/6J background

adipose tissue

increased fat cell size ( J:77909 )

• when fed a high fat diet

abnormal fat pad morphology ( J:77909 )

• increased in white fat pad mass when fed a high fat diet

liver/biliary system

enlarged liver ( J:77909 )

• when fed a high fat diet

hepatic steatosis ( J:77909 )

• when fed a high fat diet

homeostasis/metabolism

increased circulating cholesterol level ( J:77909 )

• when fed a high fat diet

hyperlipidemia ( J:77909 )

• increased serum triglyceride and free fatty acid levels in the fed state when fed a high fat diet