Phenotypes Associated with This Genotype

Genotype
MGI:3640093

• Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:51834 )

• double mutant embryos survive on average of 2 days longer than Brca1^tm1Cxd single homozygous embryos

• at E10.5, all double homozygous embryos are dead or dying

embryo

decreased embryo size ( J:51834 )

abnormal embryonic tissue morphology ( J:51834 )

• morphologically abnormal compared to controls

cellular

abnormal chromosome number ( J:51834 )

• 29% of cells contained more than 40 chromosomes and 43% of cells contained less than 40 chromosomes

spontaneous chromosome breakage ( J:51834 )

• many cells show chromosomal rearrangements such as translocations and dicentric chromosomes

growth/size/body

decreased embryo size ( J:51834 )