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Phenotypes Associated with This Genotype
Genotype
MGI:3639744
Allelic
Composition
Fgfr3tm2Wei/Fgfr3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm2Wei mutation (0 available); any Fgfr3 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Anatomical defects of the Fgfr3tm2Wei/Fgfr3+ mouse

growth/size/body
• rounded head is seen as early as 10 days of age (J:54829)
• rounded head is seen as early as 10 days of age (J:54829)
• incisors do not align properly and protrude because of changes in the skull (J:54829)
• incisors do not align properly and protrude because of changes in the skull (J:54829)
• overgrowth or incisor teeth (J:54829)
• overgrowth or incisor teeth (J:54829)
• weight is half or less that of wild-type (J:54829)
• when teeth are shortened to allow normal food intake, the weight still does not exceed 60% of the wild-type (J:54829)
• weight is half or less that of wild-type (J:54829)
• when teeth are shortened to allow normal food intake, the weight still does not exceed 60% of the wild-type (J:54829)

skeleton
• rounding of the braincase (J:54829)
• rounding of the braincase (J:54829)
• extreme shortening and distortion of the frontal bone (J:54829)
• extreme shortening and distortion of the frontal bone (J:54829)
• ventral and anterior shift of the interparietal and occipital bones which brings the foramen magnum to the base of the skull (J:54829)
• ventral and anterior shift of the interparietal and occipital bones which brings the foramen magnum to the base of the skull (J:54829)
• distortion of the parietal bones (J:54829)
• distortion of the parietal bones (J:54829)
• distortion of the maxilla (J:54829)
• distortion of the maxilla (J:54829)
• extreme shortening of the nasal bone (J:54829)
• extreme shortening of the nasal bone (J:54829)
• incisors do not align properly and protrude because of changes in the skull (J:54829)
• incisors do not align properly and protrude because of changes in the skull (J:54829)
• proliferative zone is devoid of the characteristic chondrocyte columns (J:54829)
• proliferative zone is devoid of the characteristic chondrocyte columns (J:54829)
• hypertrophic zone is considerably reduced or absent (J:54829)
• hypertrophic zone is considerably reduced or absent (J:54829)
• shortening and disorganization of the growth plate (J:54829)
• shortening and disorganization of the growth plate (J:54829)
• shortening and disorganization of the growth plate (J:54829)
• shortening and disorganization of the growth plate (J:54829)
• show an overt anterior gibbus probably due to the nearly perpendicular angle between the skull and the cervical vertebrae (J:54829)
• show an overt anterior gibbus probably due to the nearly perpendicular angle between the skull and the cervical vertebrae (J:54829)

craniofacial
• rounding of the braincase (J:54829)
• rounding of the braincase (J:54829)
• extreme shortening and distortion of the frontal bone (J:54829)
• extreme shortening and distortion of the frontal bone (J:54829)
• ventral and anterior shift of the interparietal and occipital bones which brings the foramen magnum to the base of the skull (J:54829)
• ventral and anterior shift of the interparietal and occipital bones which brings the foramen magnum to the base of the skull (J:54829)
• distortion of the parietal bones (J:54829)
• distortion of the parietal bones (J:54829)
• distortion of the maxilla (J:54829)
• distortion of the maxilla (J:54829)
• extreme shortening of the nasal bone (J:54829)
• extreme shortening of the nasal bone (J:54829)
• incisors do not align properly and protrude because of changes in the skull (J:54829)
• incisors do not align properly and protrude because of changes in the skull (J:54829)
• incisors do not align properly and protrude because of changes in the skull (J:54829)
• incisors do not align properly and protrude because of changes in the skull (J:54829)
• overgrowth or incisor teeth (J:54829)
• overgrowth or incisor teeth (J:54829)

limbs/digits/tail

Mouse Models of Human Disease
OMIM ID Ref(s)
Achondroplasia; ACH 100800 J:54829


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory