Mouse Genome Informatics
ht
    Fgfr3tm2Wei/Fgfr3+
involves: 129S1/Sv * 129X1/SvJ * MF1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Anatomical defects of the Fgfr3tm2Wei/Fgfr3+ mouse

growth/size/body
• rounded head is seen as early as 10 days of age
• incisors do not align properly and protrude because of changes in the skull
• overgrowth or incisor teeth
• weight is half or less that of wild-type
• when teeth are shortened to allow normal food intake, the weight still does not exceed 60% of the wild-type

skeleton
• rounding of the braincase
• extreme shortening and distortion of the frontal bone
• ventral and anterior shift of the interparietal and occipital bones which brings the foramen magnum to the base of the skull
• distortion of the parietal bones
• distortion of the maxilla
• extreme shortening of the nasal bone
• incisors do not align properly and protrude because of changes in the skull
• proliferative zone is devoid of the characteristic chondrocyte columns
• hypertrophic zone is considerably reduced or absent
• shortening and disorganization of the growth plate
• shortening and disorganization of the growth plate
• show an overt anterior gibbus probably due to the nearly perpendicular angle between the skull and the cervical vertebrae

craniofacial
• rounding of the braincase
• extreme shortening and distortion of the frontal bone
• ventral and anterior shift of the interparietal and occipital bones which brings the foramen magnum to the base of the skull
• distortion of the parietal bones
• distortion of the maxilla
• extreme shortening of the nasal bone
• incisors do not align properly and protrude because of changes in the skull
• incisors do not align properly and protrude because of changes in the skull
• overgrowth or incisor teeth

limbs/digits/tail

Mouse Models of Human Disease
OMIM IDRef(s)
Achondroplasia; ACH 100800 J:54829