Phenotypes Associated with This Genotype

Genotype
MGI:3639515

• Allelic Composition: Cacng8^tm1Ran/Cacng8^tm1Ran
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synaptic transmission ( J:102515 )

• excitatory synaptic transmission in hippocampal slices is impaired by ~35% in mutant mice

• AMPA/NMDA ratio of the EPSC is reduced by ~ 30%

reduced long-term potentiation ( J:102515 , J:179775 )

• LTP is reduced by 75% compared to wild-type (J:102515)

decreased miniature excitatory postsynaptic current amplitude ( J:197912 )

• reduced mEPSC amplitude

• however, there is no impact on decay