Phenotypes Associated with This Genotype

Genotype
MGI:3639144

• Allelic Composition: Penk^tm1Jep/Penk^tm1Jep
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavioral response to addictive substance ( J:109209 )

• compared to control, no significant differences in the global withdrawal score under the same chronic treatment of morphine

• develop a level of physical dependence that is at least comparable with that of wild-type mice control

abnormal chemically-elicited antinociception ( J:109209 )

• do not develop analgesic tolerance to morphine