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Phenotypes Associated with This Genotype
Genotype
MGI:3639130
Allelic
Composition
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1tm1Gru mutation (12 available); any H2-Ab1 mutation (41 available)
Tg(HLA-DRB1)31Dmz mutation (1 available)
Tg(Ins2-CD80)3B7Flv mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• transgenic mice develop sialadenitis and severity is associated with diabetes development

immune system
• transgenic mice develop sialadenitis and severity is associated with diabetes development
• expression of the DR4 transgene increases CD4+ T cell numbers compared to the H2-Ab1-deficient Tg(Ins2-CD80)3B7Flv mice
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8
• incidence of diabetes (5/20) is lower than in MHC class II-deficient mice expressing the DQ8 transgene where incidence is 3-fold higher (73%)

hematopoietic system
• expression of the DR4 transgene increases CD4+ T cell numbers compared to the H2-Ab1-deficient Tg(Ins2-CD80)3B7Flv mice
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8

digestive/alimentary system
• transgenic mice develop sialadenitis and severity is associated with diabetes development

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:68641


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory