Mouse Genome Informatics
phenotype observed in females
phenotype observed in males
N normal phenotype
• from 8 weeks of age, mice display elevated body weight compared to wild-type littermates; at 6 months of age, males are 32% heavier than wild-type littermates and females are 68% heavier
• from 8 weeks of age and during the length of the study, mice remain more obese than wild-type controls on a breeder diet (21% calories from fat)

• over a week, mice eat 13% more than wild-type controls

• at 26 weeks, leptin levels are increased in females 94 mg/ml vs control 13 mg/ml)
• mice show a trend to decreased (10%) metabolic rate vs controls

endocrine/exocrine glands
• testes show a significant decrease in weight

adipose tissue
• weight difference is due to increase in fat mass in males and females on all diets tested
• there is massive adipocyte hypertrophy with a 10- to 100-fold increase in adipocyte volume compared to wild-type littermates

reproductive system
• testes show a significant decrease in weight
• males and females reproduce but less frequently compared to controls

• on normal chow diet, mice exhibit muscle mass reduction
• on a breeder diet, mice show increased muscularity

Mouse Models of Human Disease
Obesity 601665 J:109531