Phenotypes Associated with This Genotype

Genotype
MGI:3629780

• Allelic Composition: Slc6a4^tm1Grch/Slc6a4^tm1Grch
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal active avoidance behavior ( J:109542 )

• null mice exhibit longer latencies to escape foot shock and a higher rate of escape failures

abnormal response to new environment ( J:109542 )

• null mice display a longer latency to begin feeding in a novel environment compared to wild-type; female mice exhibited longer latencies compared to males, irrespective of genotype

abnormal fear/anxiety-related behavior ( J:109542 )

• in a forced swim test paradigm, null mice display significant increases in immobility compared to wild-type

abnormal anxiety-related response ( J:109542 )

• in the elevated plus maze test, null mice display less total arm entries and had fewer head dips compared to wild-type littermates; indicating an increased level of indecision

nervous system

abnormal serotonergic neuron morphology ( J:109542 )

• null mice have significantly fewer 5HT-positive neurons in the dorsal raphe nucleus than wild-type mice

abnormal action potential ( J:109542 )

• average firing rate of serotonergic neurons in null mice is reduced ~4-fold compared to wild-type