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Phenotypes Associated with This Genotype
Genotype
MGI:3629689
Allelic
Composition
Igf1tm1Arge/Igf1tm1Arge
Igf2tm1Rob/Igf2+
Genetic
Background
either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm1Arge mutation (2 available); any Igf1 mutation (27 available)
Igf2tm1Rob mutation (1 available); any Igf2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double mutants with a paternally inherited Igf2 allele die shortly after birth of respiratory failure

growth/size/body
• birth weight is about 30% of wild-type in double mutants with a paternally inherited Igf2 allele

respiratory system

skeleton
• double mutants with a paternally inherited Igf2 allele exhibit the same developmental delays in the ossification of particular bones as the Igf1rtm1Arge single mutants

cellular
• defects are seen in double mutants with a paternally inherited Igf2 allele

integument
• the stratum spinosum is underdeveloped in double mutants with a paternally inherited Igf2 allele


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory