mortality/aging
• double mutants with a paternally inherited Igf2 allele die shortly after birth of respiratory failure
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growth/size/body
• birth weight is about 30% of wild-type in double mutants with a paternally inherited Igf2 allele
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respiratory system
skeleton
• double mutants with a paternally inherited Igf2 allele exhibit the same developmental delays in the ossification of particular bones as the Igf1rtm1Arge single mutants
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cellular
• defects are seen in double mutants with a paternally inherited Igf2 allele
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integument
• the stratum spinosum is underdeveloped in double mutants with a paternally inherited Igf2 allele
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