Phenotypes Associated with This Genotype

Genotype
MGI:3629680

• Allelic Composition: Igf1r^tm1Arge/Igf1r^tm1Arge; Igf2^tm1Rob/Igf2⁺
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15108 )

• double mutants with a paternally inherited Igf2 allele die immediately after birth of respiratory failure

growth/size/body

decreased birth weight ( J:15108 )

• birth weight is about 30% of wild-type in double mutants with a paternally inherited Igf2 allele

nervous system

abnormal nervous system morphology ( J:15108 )

• the central nervous system of double mutants with a paternally inherited Igf2 allele exhibits the same high cellular density seen in Igf1r single mutants

respiratory system

respiratory failure ( J:15108 )

skeleton

delayed bone ossification ( J:15108 )

• delays in bone development are somewhat more pronounced in double mutants with a paternally inherited Igf2 allele than in Igf1r single mutants

cellular

maternal imprinting ( J:15108 )

• defects are seen in double mutants with a paternally inherited Igf2 allele

integument

abnormal epidermal layer morphology ( J:15108 )

• double mutants with a paternally inherited Igf2 allele exhibit an underdeveloped epidermis similar to that seen in Igf1r single mutants