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Phenotypes Associated with This Genotype
Genotype
MGI:3629212
Allelic
Composition
Ucn2tm1Pbl/Ucn2tm1Pbl
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ucn2tm1Pbl mutation (0 available); any Ucn2 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• female mutants show a blunted peak of early nocturnal drinking and tend to drink more at the diurnal nadir of drinking, so that they exhibit a significantly reduced amplitude of the circadian rhythm of drinking
• fenfleuramine treatment of female mutants exhibit a smaller decrease (19%) in food intake compared to treated wild-type controls (47%)
• male mutants show a further reduced intake in the 3-12 hour period after the initial anorectic period (0-3 hours) after fenfleuramine treatment)
• female mutants show increased mobility in a forced-swim test compared to wild-type mice
• female mutants are less immobile in the tail suspension test compare to wild-type mice

homeostasis/metabolism
• evening basal (pre-stress) levels are higher in mutant females but not males than in wild-type controls
• evening basal (pre-stress) levels are higher in mutant females but not males than in wild-type controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory