Phenotypes Associated with This Genotype

Genotype
MGI:3629212

• Allelic Composition: Ucn2^tm1Pbl/Ucn2^tm1Pbl
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal drinking behavior ( J:108744 )

♀ • female mutants show a blunted peak of early nocturnal drinking and tend to drink more at the diurnal nadir of drinking, so that they exhibit a significantly reduced amplitude of the circadian rhythm of drinking

decreased food intake ( J:108744 )

• fenfleuramine treatment of female mutants exhibit a smaller decrease (19%) in food intake compared to treated wild-type controls (47%)

• male mutants show a further reduced intake in the 3-12 hour period after the initial anorectic period (0-3 hours) after fenfleuramine treatment)

abnormal locomotor activation ( J:108744 )

♀ • female mutants show increased mobility in a forced-swim test compared to wild-type mice

♀ • female mutants are less immobile in the tail suspension test compare to wild-type mice

homeostasis/metabolism

increased circulating corticosterone level ( J:108744 )

♀ • evening basal (pre-stress) levels are higher in mutant females but not males than in wild-type controls

increased circulating adrenocorticotropin level ( J:108744 )

♀ • evening basal (pre-stress) levels are higher in mutant females but not males than in wild-type controls