Analysis Tools
mortality/aging
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• die between E11.5 and E12.5
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embryo
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• in E8.5 embryos
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• although embryos exhibit fusion of the allantois with the chrion by E8.5, there is a significant increase in apoptotic cells
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• see many necrotic cells in the neuroepithelium of the brain by E11.5 and lysis of head and trunk mesenchyme tissue
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• the neuroepithelial mesenchyme has sparse cells
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• the neuroepithelium has sparse cells
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• at E8.5, the chorion is organized as a chorionic plate and lacks fetal blood vessels
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• by E9.5, the spongiotrophoblast layer remains significantly underdeveloped
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• by E9.5, the labyrinthine layer remains significantly underdeveloped
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• by E9.5, the placenta is less than half the normal size
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nervous system
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• the neuroepithelium has sparse cells
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cardiovascular system
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• embryos exhibit dilated blood vessels
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• exhibit apoptotic cells in the heart
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hemorrhage
(
J:78546
)
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• exhibit widespread hemorrhages in all organs by E11.5
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cellular
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• in E8.5 embryos
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• although embryos exhibit fusion of the allantois with the chrion by E8.5, there is a significant increase in apoptotic cells
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• see many necrotic cells in the neuroepithelium of the brain by E11.5 and lysis of head and trunk mesenchyme tissue
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• all defects are seen in F2 heterozygotes that receive the mutant allele from the mother, while all F1 heterozygotes that receive the mutant allele from the father are normal
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