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Phenotypes Associated with This Genotype
Genotype
MGI:3628916
Allelic
Composition
Dnmt3btm1Enl/Dnmt3btm7Enl
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3btm1Enl mutation (1 available); any Dnmt3b mutation (28 available)
Dnmt3btm7Enl mutation (0 available); any Dnmt3b mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• normal numbers of pups are born but most die within 24 hours

immune system
• majority of P1 mutant thymocytes are dead or dying
• thymuses of P1 mutants are much smaller than those of controls
• total number of thymocytes is reduced ~10 fold compared to wild-type
• numbers of CD4-CD8- cells are relatively increased compared to wild-type
• numbers of CD4+CD8+ cells are reduced in mutants compared to wild-type; this is similar in all mutant phenotypes (data not shown)

growth/size/body
• at birth, mutants are less than 2/3 the weight of normal littermates

hematopoietic system
• majority of P1 mutant thymocytes are dead or dying
• thymuses of P1 mutants are much smaller than those of controls
• total number of thymocytes is reduced ~10 fold compared to wild-type
• numbers of CD4-CD8- cells are relatively increased compared to wild-type
• numbers of CD4+CD8+ cells are reduced in mutants compared to wild-type; this is similar in all mutant phenotypes (data not shown)

cellular
• majority of P1 mutant thymocytes are dead or dying

endocrine/exocrine glands
• majority of P1 mutant thymocytes are dead or dying
• thymuses of P1 mutants are much smaller than those of controls
• total number of thymocytes is reduced ~10 fold compared to wild-type


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory