Mouse Genome Informatics
ot
    G6pdxa-m1Neu/Y
involves: 102/El * C3H/El * T-stock
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• aortic vessel outgrowth from explanted thoracic aortas is decreased compared to wild-type (J:85179)
• in an in vivo Matrigel angiogenesis assay, endothelial cell migration into plugs is significantly inhibited compared to wild-type (J:85179)
• exhibit increased susceptibility to ischemia-reperfusion injury; on reperfusion, cardiac relaxation and contractile performance are impaired as shown by elevated end-diastolic pressures and decreased percent recovery of developed pressure relative to wild type (J:102347)
• with ischemia-reperfusion, hearts exhibit increased susceptibility to cellular thiol depletion and redox imbalance relative to wild-type (J:102347)

cellular
• induction of sepsis results in an elevation of plasma glutathione levels, indicating greater sepsis-induced oxidative stress than in wild-type (J:95754)

hematopoietic system
N
(J:13991)
• although hemizygotes only have 15% G6pdx remaining activity in the blood, observe no differences in hematocrit values, red blood-cell counts, hemoglobin content, in the osmotic-fragility of red blood cells, in plasma glucose concentration, in glucose consumption in blood, or in body weight and exhibit no chronic hemolysis under normal conditions (J:58685)
• erythrocyte deformability is decreased in younger erythrocyte subpopulations from septic mutants compared with wild-type (J:95754)
• induction of sepsis results in a decrease in red blood cell counts compared to wild-type (J:95754)
• induction of sepsis results in a decrease in blood hemoglobin content and an increase in plasma hemoglobin content compared to septic wild-type mice (J:95754)
• mean corpuscular hemoglobin content is decreased in younger erythrocyte subpopulations from septic mutants compared with wild-type (J:95754)
• induction of sepsis results in hemolysis and anemia that is not observed in wild-type (J:95754)
• exhibit worse erythrocyte dysfunction during sepsis than wild-type, with increased erythrocyte rigidity and tendency for hemolysis (J:95754)

homeostasis/metabolism
• exhibit increased susceptibility to ischemia-reperfusion injury; on reperfusion, cardiac relaxation and contractile performance are impaired as shown by elevated end-diastolic pressures and decreased percent recovery of developed pressure relative to wild type (J:102347)
• with ischemia-reperfusion, hearts exhibit increased susceptibility to cellular thiol depletion and redox imbalance relative to wild-type (J:102347)