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Phenotypes Associated with This Genotype
Genotype
MGI:3628830
Allelic
Composition
Dnmt3btm6Enl/Dnmt3btm6Enl
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3btm6Enl mutation (0 available); any Dnmt3b mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• normal numbers of pups are born but most die within 24 hours (J:106540)
• normal numbers of pups are born but most die within 24 hours (J:106540)

craniofacial
• enlarged front fontanelle is present in mutants (J:106540)
• enlarged front fontanelle is present in mutants (J:106540)
• calvarium of adult homozygotes has wider frontal bones than wild-type littermates resulting in a wider distance between the eyes (J:106540)
• calvarium of adult homozygotes has wider frontal bones than wild-type littermates resulting in a wider distance between the eyes (J:106540)
• nasal bone of adults is shorter than in wild-type (J:106540)
• nasal bone of adults is shorter than in wild-type (J:106540)

growth/size/body
• at birth, mutants are less than 2/3 the weight of normal littermates (J:106540)
• at birth, mutants are less than 2/3 the weight of normal littermates (J:106540)

hematopoietic system
• at P1, many thymocytes are dead or dying (J:106540)
• at P1, many thymocytes are dead or dying (J:106540)
• thymuses of P1 mutants are much smaller than those of controls (J:106540)
• thymuses of P1 mutants are much smaller than those of controls (J:106540)

immune system
• at P1, many thymocytes are dead or dying (J:106540)
• at P1, many thymocytes are dead or dying (J:106540)
• thymuses of P1 mutants are much smaller than those of controls (J:106540)
• thymuses of P1 mutants are much smaller than those of controls (J:106540)

skeleton
• enlarged front fontanelle is present in mutants (J:106540)
• enlarged front fontanelle is present in mutants (J:106540)
• calvarium of adult homozygotes has wider frontal bones than wild-type littermates resulting in a wider distance between the eyes (J:106540)
• calvarium of adult homozygotes has wider frontal bones than wild-type littermates resulting in a wider distance between the eyes (J:106540)
• nasal bone of adults is shorter than in wild-type (J:106540)
• nasal bone of adults is shorter than in wild-type (J:106540)

vision/eye
• mutants display a wider distance between the eyes (J:106540)
• mutants display a wider distance between the eyes (J:106540)

cellular
• at P1, many thymocytes are dead or dying (J:106540)
• at P1, many thymocytes are dead or dying (J:106540)

endocrine/exocrine glands
• at P1, many thymocytes are dead or dying (J:106540)
• at P1, many thymocytes are dead or dying (J:106540)
• thymuses of P1 mutants are much smaller than those of controls (J:106540)
• thymuses of P1 mutants are much smaller than those of controls (J:106540)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory