Phenotypes Associated with This Genotype

Genotype
MGI:3625925

• Allelic Composition: Sox2^tm1Lpev/Sox2^tm4Lpev
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

optic nerve hypoplasia ( J:108452 )

• show hypoplasia of optic nerves and chiasmata by gross morphological analyses of brain

microphthalmia ( J:108452 )

• a range of eye phenotypes from mild bilateral microphthalmia to severe anophthalmia

disorganized retina layers ( J:108452 )

• disrupted cell layering consisting of rosette structures

• retinal ganglion cells are inappropriately localized

retina hyperplasia ( J:108452 )

• 30%-40% thinner than wild-type retinas

• reduction in cell number

anophthalmia ( J:108452 )

• a range of eye phenotypes from mild bilateral microphthalmia to severe anophthalmia

nervous system

optic nerve hypoplasia ( J:108452 )

• show hypoplasia of optic nerves and chiasmata by gross morphological analyses of brain